Organic Growth Factor
Organic Growth Factor
Muscle building & Growth Hormone for Dummees
Muscle Labs USA specializes in the use of hormones for athletic enhancement purposes. Growth hormone (GH) has been surrounded by a cloud of mystique for many years carried by whispered hushes of freak status and a shot at the Mr. O for those who venture its use. Warnings of facial disfigurement and hopes of sexual appendage elongation alike have accompanied the strange tales of this hormone’s power.
The truth is that GH works very well if it is properly employed. If An athlete has trained and eaten correctly the net gain in lean tissue mass can be as much as a 14% increase in total lean mass in a matter of weeks with a similar corresponding loss in adipose (fat) tissue. But the effects are far positive effects of a GH protocol can be far reaching in that the protocol allows continued progress where none has been realized for quite some time. Many lose much of the potential possible progress during the actual GH protocol and almost all give up the long-term gains that they could have realized by simply understanding a few facts of reality concerning GH use. Employment of these facts usually results in realizing the 14% net gain possible and keeping them post-protocol while adding a few more freaky pounds. Been there done that.
There are several hormones, hormone-like substances, and a few supplements that act anabolically enough to result in an increase in lean muscle mass without any degree of androgenic activity. Many of these substances are highly anti-catabolic as well. If an athlete’s goal is to make continuous progress either an anabolic or anti-catabolic environment must be maintained without creating uncontrolled negative reactions to the intended anabolic or anti-catabolic action. In the case of Absolute Anabolics this means that the anabolic signaling method must be phased or cycled in the appropriate time frames as well as utilization of the correct products to aid an athlete in working with instead of against their bodies. We will first discuss the hormone and then discuss OTC products that either positively affect them or those that mimic their activity.
Growth Hormone (GH) GH is probably the best known of the hormones we refer to as Absolute Anabolics. GH is often heralded to be a fountain of youth for the aging and a mandatory addition to the drug protocols of the elite competitive athlete. It is also naturally produced within the body.
The average healthy adult produces between 0.5-1.5 iu (international units) of GH daily. This is not to say that the body cannot produce a great deal more GH, only that this is all the body wants to produce for our declining post-adolescent years. (Which really sucks) After all, we are past our hormonal prime as males at age 18-25 (yet we are not in our muscular prime for well over a decade after).
There are two types of muscle proteins capable of growth are structural and contractile proteins.Contractile proteins are called actin and myosin. Their job is to induce body movement through contractions that result in the shortening of the muscle fibers. This is quite similar to a ratcheting effect in action. The structural proteins hold the entire muscle and connective tissue complex together. Both proteins add to total muscle mass, strength potential and density. GH has a profound positive effect upon structural protein anabolism while providing a degree of increased protein synthesis within contractile proteins. Additionally, GH use results in a very powerful anticatabolic effect. By increasing total structural protein content we realize a very obvious increase in lean muscle mass and strength potential while benefiting actual structural integrity. This is important when considering long-term potential and results. Structural integrity can be a dramatic limiting factor or growth stimulus. The lack of supporting tissues obviously also limits potential training weight-loads for the affected muscle groups. Therefore a greater degree of structural protein synthesis results in an increase in contractile protein synthesis due to adaptation to a greater weight-load.
There are a few other benefits to increased GH levels to consider: *Increased lean mass tissue *Improved memory *Increased strength *Improved stamina *Increased Libido *Stronger bones *Lower blood pressure *Lower bodyfat percentage *Increased rate of recovery and regeneration of tissues *Regeneration of skin proteins and improved skin elasticity *Anticatabolic/lean tissue sparing during calorie restricted periods *Increased use of fat stores as an energy source.
Many of the effects of GH can be attributed to the known 8 growth factors resulting from its elevation in the circulatory system. Of these the most noted growth factor in the sports community is IGF-1, and less so FGF. Many who have used GH with poor results simply did not realize the chain of events that GH use induces and therefore missed the long-term gains that they had at their finger-tips. Of course some simply totally screwed up the protocol.
When GH binds to its healthy muscle cell receptor, several good things happen: The cell increases IGF-1 production. The cell switches to favoring fat as a main energy source. An increase in structural protein synthesis occurs (anabolism) The up-take of the other half of the necessary amino acids for cell growth significantly increases.
Thyroid Hormones regulate the body’s metabolic rate. That is: The rate at which cells absorb and utilize calories. The rate of protein synthesis occurs. The rate at which fat is oxidized (burned).
*The liver readily forms circulatory IGF-1 in the presence of GH and Insulin. Metabolically active cells secrete IGF-1 as a result of meeting up with GH, estrogens, or as a result of a chemical cascade originating from cellular and tissue elongation (stretching).
The human body is an amazingly adaptive organism that is basically lazy. In short it fights change by doing as little as possible. The body prefers to slowly degrade into mediocrity through preservation of homeostasis. Homeostasis simply means a state of no change. Yup: Weenie status. Anytime the hormone ratio/profile that supports this slide in the oblivion is altered the body either attempts to shut down the offending organ or gland, or inhibits the effect at the cellular level. Obviously GH and its growth factor substrates are no different in this aspect.
Control Of The GH/IGF-1 Axis: There are two recognized peptide hormones known to regulate the body’s GH levels. When the hypothalamus secretes GHRH (growth hormone releasing hormone) it contacts its receptors of the pituitary gland resulting in a pulsitile release of GH. If there were no inhibiting hormone, or negative feed-back loop, the levels of circulatory GH and resulting IGF-1 would reach a very profound measure indeed (Oh darn). Somatostatin is the hormone that tells the pituitary to decrease or stop GH secretion. But of course it does not stop there. Somatostatin triggers GH/IGF-1 receptor down-regulation and a decrease in sensitivity as well as acting to decrease the secretion of TSH (thyroid stimulating hormone). The result is a decrease in metabolic rate and a reduction in net anabolism. Sucks, huh? Ya, so does the correlating decrease in calorie expenditure from fat stores and an increase in muscle catabolism (fat dude status). So, all we have to do is decrease or stop the somatostatin release and shredded freak status will soon be ours…right?
There is a second inhibitive pathway to regulate GH levels is called a negative feed-back loop. When circulatory GH or Somatostatin makes its way back to the hypothalamus and/or the pituitary gland the over abundance of either will shut down its own respective receptors as well.
Bottom-Line When an athlete administers supraphysiological dosages of GH for a prolonged period of time without correctly anticipating and responding to Action/Reaction Factors the pituitary and hypothalamus respond to the increasing negative feed-back loop by shutting down first GHRH release and second shutting off the GH supply. So GH release is suppressed on two levels. Next the release of Somatostatin gradually increases to beyond normal levels to further inhibit what the body assumes to be pituitary release of GH. Of course the GH/IGF-1 receptors are beaten up pretty bad by the chronic elevation of Somatostatin and the dosages of GH administered are required to increase to match. During the protocol this means higher dosages with fewer returns and post protocol it means suppressed endogenous GH secretion and a great deal of lean tissue loss. Not bad enough? How about the fat accumulation and loss of long term results?
For Every Action There Is A Profitable Reaction The human physiology commonly begins a significant multi-level fight for homeostasis against exogenous GH use at just over the 14 day continuous administration period. This is due to an increase in Somatostatin and a down-regulation of GHRH release. The result is a decrease in GH/IGF-1 receptor sensitivity and a shut-down in GH secretion by the pituitary respectively.
Estrogens promote cellular and hepatic IGF-1 secretion and pituitary release of GH. Though it seems that most high androgens can inhibit this process to some extent, those that foster its formation tend to promote it…as do certain blood meds employed to control the elevation in blood pressure realized from estrogen induced water retention.
A few chemicals called GH secretagogues have shown the unique ability to restore the GH/IGF-1 Axis to normal function. In fact some of these drugs have been clinically documented to elicit GH release levels as much as 40 times normal with consecutive dosages realizing nearly the same degree of elevation…multiple times daily. The down fall of GH secretagogues drugs like MK-677, Hexarelin and GHRP-2 is that the body begins to react to them as well after a bout 2 weeks with a decrease in GH secretion of about 40%. Human Growth hormones hardly prove to be any more effective than anabolic steroids for most sport specific regimens. Never rely on any magic bullet to be your guaranteed solution for rapid muscle gains. Explore legal anabolic alternatives and remember to…..
Train hard, eat quality meals and grow big.
why will my pyrethrum not grow?
I live in a wanna-be organic farm. I have planted several seeds of pyrethrum for insecticide. All web sites say it loves plenty of sun, moist dirt and that’s it. I live in Costa Rica, it’s the rainy season, yet my little plants stop at one or two inches, and for now they are in potting soil. What factor is inhibiting their growth? Thanks.
There is something called damping off. It causes the seedlings to stop growing and die. It is usually a soil born fungus and the damp weather you describe helps the problem. Here are some sites that may help you.
http://tomclothier.hort.net/page13.html
http://www.uvm.edu/pss/ppp/pubs/gd9.htm
http://www.gardenersnet.com/atoz/dampingoff.htm
Acure Organics: the miracle of chlorella growth factor (CGF)
[groupmage source="groupon" location=0 display=5]
[groupmage source="crowdsavings" location=1 display=5]
|
|
P3 International P4400 Kill A Watt Electricity Usage Monitor $50.00 Empowers You to Save Hundreds on Electric Bills Electricity bills are rising. Now you can cut down on costs and find out what appliances are actually worth keeping plugged in. Simply connect these appliances to the Kill A Watt, and it will assess how efficient they really are. The large LCD display counts consumption by the kilowatt-hour, the same as your local utility. You can calculate your elec… |
|
|
Bluelab Guardian pH, Conductivity and Temperature Monitor $269.95 In just one glance the Guardian Monitor measures all three critical parameters to successful growth; pH, conductivity and temperature. Seasonal changes, sunlight hours, wind, inherent plant growth; from vegetative to fruiting; are all influencing factors to plant growth success. More importantly…these parameters change the plants uptake and need of water and specific nutrient elements. The Blue… |
|
|
Lactic Acid 50% Gel Peel – Enhanced with Kojic Acid & Bearberry Extract (Professional Chemical Peel) $19.49 Professionally formulated to even skin tone and effectively lighten pigmentation by inhibiting the enzyme responsible for producing excess melanin. Lactic Acid has been well-known to reduce the appearance of scars, age spots, sunspots, and discoloration associated with acne or photo-damaged skin. Lactic also promotes stimulation of collagen production, while increasing cell turn over rate, for a m… |
|
|
Source Naturals Broken Cell Wall Chlorella, Pure Micro-Algae, 500mg, 200 Tablets (Pack of 2) $28.68 Dietary supplement. Chlorella are green, single-cell micro-algae and perhaps the world’s most nutritious food. Chlorella is the only source of Chlorella Growth Factor (CGF), the richest source of chlorophyll, and over 50% protein. Our chlorella is careful… |
|
|
Bee Sunny SPF 35 Mineral Powder Sunscreen Zinc Oxide & Titanium $17.86 Our Bee Sunny mineral sunblock is a great way to create protection while outdoors. It is easy to apply and very effective. Just apply in a grid pattern to ensure even coverage. The combination of uva and uvb broad sprectrum sunscreen coverage comes for 17% active ingredients including Zinc and Titanium. Zinc is an essential mineral required by the body for maintaining a sense of smell, keepi… |
|
|
Effect of loganin on experimental diabetic nephropathy.(Report): An article from: Phytomedicine: International Journal of Phytotherapy & Phytopharmacology $9.95 … |
|
|
Organic nutrient factors effecting algal growths, (Ecological research series) … |